Prof Keun-Ah Cheon | Innovative Leadership | Best Researcher Award

Prof Keun-Ah Cheon | Innovative Leadership | Best Researcher Award

Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea

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Early Academic Pursuits 🎓

Dr. Keun-Ah Cheon’s academic journey began at Yonsei University College of Medicine, one of South Korea’s most prestigious medical schools. She earned her Doctor of Medicine (M.D.) degree in 1994 after completing her six-year program, laying the foundation for her career in psychiatry. She pursued a Master’s degree in Medical Science from the same institution between 1996 and 1999. Her master’s thesis, titled “The Effect of Haloperidol on Regional Cerebral Blood Flow Assessed with 99m-Tc-ECD SPECT in Schizophrenic Patients,” reflected her early interest in understanding the neurological underpinnings of psychiatric disorders.

Dr. Cheon’s academic journey continued with a Doctor of Philosophy (Ph.D.) in Child and Adolescent Psychiatry, also from Yonsei University, where she developed a diagnostic instrument for Korean children with ADHD and explored the genetic links between ADHD and the Dopamine D4 receptor gene (DRD4). This work was pivotal in expanding the understanding of ADHD in the South Korean context, aligning her research with both clinical practice and genetic psychiatry.

Professional Endeavors 🩺

Dr. Cheon’s professional career took off at Kwandong University College of Medicine, where she served as Assistant Professor and Director of Child and Adolescent Psychiatry from 2003 to 2008. Her leadership in this role set a strong foundation for her future endeavors. During this period, Dr. Cheon not only contributed to the academic community but also gained hands-on experience as the Director of Child and Adolescent Psychiatry, solidifying her reputation as a leading expert in the field.

In 2009, Dr. Cheon expanded her horizons with a year-long visiting scholar position at the Developmental Neuroimaging Laboratory in the Center for Autism Research at Children’s Hospital of Philadelphia, part of the University of Pennsylvania School of Medicine. This experience exposed her to cutting-edge research in developmental neuroimaging, enabling her to apply advanced techniques and global perspectives to her work in South Korea.

Upon returning to Yonsei University College of Medicine, Dr. Cheon was promoted to Associate Professor in 2010, continuing to direct the Division of Child and Adolescent Psychiatry. In 2017, she was promoted to Professor, a position she continues to hold, making substantial contributions to psychiatric education and research.

Contributions and Research Focus 🧠

Dr. Cheon’s research interests span several critical areas of child and adolescent psychiatry, with a particular focus on developmental disorders such as ADHD and autism. Her early research centered on understanding the genetic foundations of ADHD, specifically investigating the association between ADHD and the Dopamine D4 receptor gene (DRD4). This focus on neurobiological mechanisms highlighted her commitment to bridging clinical psychiatry with molecular science.

As Director of the Severance Autism and Developmental Disorder Center since 2023, Dr. Cheon has expanded her research into autism spectrum disorders. Under her leadership, the center has become a hub for innovative research and treatment strategies, designated by South Korea’s Ministry of Health and Welfare. This role also underscores her ability to translate research findings into real-world therapeutic interventions for children with developmental disorders.

Her contributions are not limited to clinical psychiatry and research; Dr. Cheon is actively involved in the development of diagnostic tools tailored to the South Korean population, reflecting her focus on culturally sensitive psychiatric care. She has made significant strides in improving the understanding of child and adolescent mental health issues in the local context, contributing to a body of work that has influenced national policies and practices.

Accolades and Recognition 🏅

Dr. Cheon’s dedication to the field has earned her numerous accolades. Since March 2024, she has been serving as the President of the Korean Academy of Child and Adolescent Psychiatry (KACAP), a prestigious role that recognizes her leadership and expertise in the field. Her election to this position is a testament to her influence and the respect she commands within the psychiatric community in South Korea.

Additionally, her leadership roles at Yonsei University and beyond have further solidified her reputation as a key figure in psychiatric research and education. As Deputy Director of the Institute of Behavioral Science in Medicine and Director of the Department of Child and Adolescent Psychiatry, Dr. Cheon plays a crucial role in shaping psychiatric research and clinical practice.

Impact and Influence 🌍

Dr. Cheon’s influence extends beyond South Korea. Her work in neuroimaging, autism, and ADHD has earned international recognition, particularly her collaboration with the Center for Autism Research at the Children’s Hospital of Philadelphia. This experience allowed her to integrate global best practices into her research and clinical work, contributing to improved diagnostic and treatment methodologies in South Korea.

As an educator, Dr. Cheon has mentored countless students, residents, and fellows in psychiatry, shaping the next generation of child and adolescent psychiatrists. Her role as a professor at Yonsei University has provided her with a platform to share her expertise and knowledge, influencing both clinical practice and psychiatric education.

Legacy and Future Contributions 🌟

Looking forward, Dr. Cheon’s contributions are poised to leave a lasting legacy in child and adolescent psychiatry. Her leadership at the Severance Autism and Developmental Disorder Center and her presidency at KACAP indicate that she will continue to be a driving force in shaping the future of psychiatric care and research in South Korea.

Her ongoing work in understanding the genetic basis of psychiatric disorders, combined with her commitment to improving diagnostic tools and therapeutic interventions, will likely lead to groundbreaking advancements in the field. As a trailblazer in child and adolescent psychiatry, Dr. Cheon’s influence will undoubtedly continue to grow, ensuring her legacy as a leader in both South Korean and global psychiatry.

Conclusion 🔍

Dr. Keun-Ah Cheon’s career exemplifies a dedication to improving the understanding and treatment of psychiatric disorders in children and adolescents. From her early academic pursuits at Yonsei University to her current leadership roles, her contributions to psychiatry have had a profound impact both nationally and internationally. Through her research, clinical work, and mentorship, Dr. Cheon has cemented her place as a pivotal figure in child and adolescent mental health, and her legacy will continue to shape the field for years to come.

📝Notable Publications

Prevalence of autism spectrum disorders in a total population sample

Authors: Y.S. Kim, B.L. Leventhal, Y.J. Koh, E. Fombonne, E. Laska, E.C. Lim, K.A. Cheon, et al.
Journal: American Journal of Psychiatry
Volume: 168
Issue: 9
Pages: 904-912
Year: 2011

Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

Authors: P.H. Lee, V. Anttila, H. Won, Y.C.A. Feng, J. Rosenthal, Z. Zhu, E.M. Tucker-Drob, et al.
Journal: Cell
Volume: 179
Issue: 7
Pages: 1469-1482.e11
Year: 2019

The reliability and validity of kiddie-schedule for affective disorders and schizophrenia-present and lifetime version-Korean version (K-SADS-PL-K)

Authors: Y.S. Kim, K.A. Cheon, B.N. Kim, S.A. Chang, H.J. Yoo, J.W. Kim, S.C. Cho, et al.
Journal: Yonsei Medical Journal
Volume: 45
Issue: 1
Pages: 81-89
Year: 2004

Characteristics of brains in autism spectrum disorder: structure, function and connectivity across the lifespan

Authors: S. Ha, I.J. Sohn, N. Kim, H.J. Sim, K.A. Cheon
Journal: Experimental Neurobiology
Volume: 24
Issue: 4
Pages: 273
Year: 2015

A comparison of DSM-IV pervasive developmental disorder and DSM-5 autism spectrum disorder prevalence in an epidemiologic sample

Authors: Y.S. Kim, E. Fombonne, Y.J. Koh, S.J. Kim, K.A. Cheon, B.L. Leventhal
Journal: Journal of the American Academy of Child & Adolescent Psychiatry
Volume: 53
Issue: 5
Pages: 500-508
Year: 2014

Ms. Kassandra Zachos | Transformational Leadership | Best Researcher Award

Ms. Kassandra Zachos | Transformational Leadership | Best Researcher Award

University of Toronto, Canada 

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Early Academic Pursuits 📚

Kassandra Alexis Zachos embarked on her academic journey at the University of Toronto, where she earned a Bachelor of Science degree in Nutritional Sciences and Fundamental Genetics. This foundational education provided her with a robust understanding of the intricate relationships between genetics, nutrition, and health. Motivated by her undergraduate studies, Kassandra pursued a Ph.D. in Pharmacology at the same institution, guided by Dr. Ana Andreazza. Her transition from genetics and nutritional sciences to pharmacology was driven by a keen interest in understanding the biochemical and physiological mechanisms underlying chronic diseases. This shift marked the beginning of her focused exploration into mitochondrial dysfunction and its implications for mood disorders and metabolic diseases.

Professional Endeavors 🏥

Kassandra’s professional career reflects a blend of academic rigor and practical application. During her time as a Ph.D. candidate, she has been deeply involved in cutting-edge research related to mitochondrial biomarkers and their role in mood disorders and metabolic diseases. Her work includes significant contributions to the development of novel therapeutics and dietary interventions aimed at improving patient outcomes. Beyond her academic research, Kassandra has also applied her expertise in a broader context, including her role as Vice President of Thomas & Co., an elevated leisure apparel company dedicated to sustainable fashion. This role underscores her commitment to making a positive impact both in and out of the academic sphere.

Contributions and Research Focus 🔬

Kassandra’s research is centered on the intersection of mitochondrial dysfunction, mood disorders, and metabolic diseases. She investigates how mitochondrial biomarkers can be used to enhance the understanding of chronic diseases and develop personalized therapeutic approaches. Her research has led to the completion of several significant projects, including the optimization of mitochondrial isolation techniques and the exploration of mitochondrial genetics in bipolar disorder. Her ongoing work aims to evaluate the role of dietary interventions in managing mitochondrial dysfunction and associated diseases. Through her innovative use of cell-based technologies and biomarker analysis, Kassandra is making strides in the field of nutritional psychiatry and personalized medicine.

Accolades and Recognition 🏆

Kassandra’s exceptional contributions to her field have been recognized through numerous awards and scholarships. Her achievements include the School of Graduate Studies Conference Grant (2023), the MITO2i Graduate Student Scholarship (2022), and multiple fellowships from the University of Toronto. These accolades not only reflect her academic excellence but also highlight her role as a leader in mitochondrial research. Her publications in prominent journals such as Psychiatry Research and Stem Cell Research & Therapy further underscore her impact on the scientific community.

Impact and Influence 🌍

Kassandra’s work has had a profound impact on the understanding of mitochondrial dysfunction and its relation to chronic diseases. By identifying and validating mitochondrial biomarkers, she is contributing to the development of more effective and personalized treatments for mood disorders and metabolic diseases. Her research on the implications of diet and mitochondrial function is paving the way for innovative approaches in nutritional psychiatry. Kassandra’s presentations at international conferences and her involvement in professional collaborations demonstrate her influence in advancing mitochondrial research and improving patient care.

Legacy and Future Contributions 🔮

Looking ahead, Kassandra’s future contributions promise to build on her current research focus. Her dedication to uncovering the mechanisms underlying mitochondrial dysfunction and developing personalized therapeutics will likely lead to further breakthroughs in the field. Her role as a leader in both academic and professional settings suggests that she will continue to shape the future of mitochondrial research and its applications in chronic disease management. Kassandra’s ongoing efforts in both her academic pursuits and professional endeavors are expected to leave a lasting legacy in the realms of pharmacology, nutrition, and sustainable fashion.

📚 Publications

Lactate in bipolar disorder: A systematic review and meta‐analysis

  • Author: Heidi Kuang, Angela Duong, Hyunjin Jeong, Kassandra Zachos, Ana C Andreazza
  • Source:  Psychiatry and clinical neurosciences
  • Year: 2018

Lactate in bipolar disorder: A systematic review and meta‐analysis

  • Author: Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids
  • Source: David F Bodenstein, Pavel Powlowski, Kassandra A Zachos, Dana El Soufi El Sabbagh, Hyunjin Jeong, Liliana Attisano, Landon Edgar, Douglas C Wallace, Ana Cristina Andreazza
  • Year: 2023

Lactate in bipolar disorder: A systematic review and meta-analysis

  • Author: H Kuang, A Duong, H Jeong, K Zachos, AC Andreazza
  • Source: BIPOLAR DISORDERS Cristina Andreazza
  • Year: 2019

Ms. Kassandra Zachos | Transformational Leadership | Best Researcher Award

Ms. Kassandra Zachos | Transformational Leadership | Best Researcher Award

University of Toronto, Canada

🔗 Professional Profiles

📋 Summary:

Kassandra Alexis Zachos is a dedicated PhD candidate in her fifth year at the University of Toronto, under the guidance of Dr. Ana Andreazza. Her research focuses on the intricate relationship between mitochondria, mood disorders, and metabolic diseases, emphasizing the role of nutrition and diet quality. Kassandra aims to uncover alternative personalized therapeutics using mitochondrial biomarkers.

🎓 Education:

  • PhD Candidate in Pharmacology, University of Toronto
  • BSc in Genetics and Nutritional Sciences, University of Toronto

💼 Professional Experience:

Kassandra has substantial experience in cell-based technologies, the generation of novel therapeutics, and nutritional supplementation. She has completed four research projects and is currently involved in three ongoing studies.

🔬 Research Interests:

Kassandra’s primary research interest is the interplay between mitochondrial dysfunction and chronic diseases, particularly mood disorders and metabolic diseases. Her work includes:

  • Translational biomarkers in stem cell models and human plasma samples.
  • Mitochondrial-targeted metabolomics.
  • Personalized therapeutic development.
  • Nutritional psychiatry.

🔗 Contact:

🌟 Key Contributions:

Kassandra’s research highlights the importance of patient stratification based on mitochondrial metabolites and the development of personalized therapeutic approaches. Her innovative work bridges the gap between mitochondrial dysfunction, mood disorders, and metabolic diseases, contributing significantly to the field of nutritional psychiatry.

🤝 Collaborations & Memberships:

  • Collaborations: 4
  • Professional Memberships: 1

📚Notable Publications

  1. Zachos KA, et al. Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder. Psychiatry Research. 2024.
  2. Bodenstein DF, et al. Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids. Stem Cell Research & Therapy. 2023.
  3. Duong A, et al. Mitochondrial Genetics and Function in Affected Families with Bipolar Disorder and Mitochondrial Disease. Bipolar Disorders. 2019.
  4. Kuang H, et al. Lactate in Bipolar Disorder: A Systematic Review and Meta-Analysis. Psychiatry Clin Neuroscience. 2018.