Assist Prof Dr. Taku Ishii | Decision-making and Problem-solving | Best Research Article Award

Assist Prof Dr. Taku Ishii | Decision-making and Problem-solving | Best Research Article Awar

Institute of Science Tokyo | Japan

Author Profile

ORCID

Early Academic Pursuits

Taku Ishii’s academic path reflects a focused dedication to understanding and addressing complex pediatric cardiovascular diseases. From the outset of his medical education, he was drawn to the intricacies of pediatric cardiology, a specialty that demands both technical precision and a deep sense of compassion. His early clinical training allowed him to develop expertise in diagnosing and managing congenital heart disease and pulmonary hypertension, conditions that profoundly affect the lives of young patients and their families. Seeking to enhance his approach to patient care, he pursued graduate studies in public health, which broadened his perspective beyond individual treatment toward the systemic and epidemiological aspects of healthcare. This unique combination of clinical and public health training equipped him with a multifaceted approach to pediatric cardiology, enabling him to address not only the biological mechanisms of disease but also the societal factors influencing patient outcomes.

Professional Endeavors

In his current role as an Assistant Professor at the Institute of Science Tokyo, Taku Ishii operates at the intersection of clinical practice, academic instruction, and research leadership. As a clinician, he provides specialized care to children with life-threatening and complex cardiac conditions, applying innovative treatment strategies to improve long-term health outcomes. His academic contributions involve mentoring medical students and residents, fostering their clinical judgment, technical skills, and dedication to compassionate care. Beyond the classroom and hospital, he actively participates in the Japanese Association of Congenital Heart Disease with Pulmonary Hypertension (JACPHR), contributing to collaborative research and nationwide efforts to advance understanding and management of these conditions. His professional life is characterized by a commitment to advancing patient care while building the capacity of the next generation of pediatric cardiologists.

Contributions and Research Focus

Taku Ishii’s research portfolio reflects his dual commitment to scientific advancement and clinical relevance. His studies encompass molecular biology, clinical cardiology, and epidemiology, creating a holistic body of work that addresses both the mechanisms and management of pediatric heart diseases. His co-authored research in The FASEB Journal explores the role of Hedgehog signaling in the development of pulmonary arterial hypertension, identifying cyclopamine as a potential therapeutic agent to mitigate disease progression. His work published in Cureus examines the role of implantable cardioverter defibrillators in preventing sudden cardiac death in children with arrhythmogenic right ventricular cardiomyopathy, providing much-needed data to guide treatment in pediatric populations. Additionally, his collaboration in the Journal of Human Genetics documents novel cases of HYAL2 deficiency, linking genetic variations to different clinical severities, and reinforcing the integration of genetic insights into pediatric cardiology. Through these contributions, he advances both the understanding of disease mechanisms and the development of patient-centered therapeutic strategies.

Accolades and Recognition

Taku Ishii’s achievements have earned him professional recognition within both national and international medical communities. His appointment as an assistant professor at the Institute of Science Tokyo underscores his standing as a respected academic and clinician. His publications in high-impact, peer-reviewed journals demonstrate the scientific rigor and clinical relevance of his work, contributing to ongoing global conversations in pediatric cardiology. His active involvement in collaborative research networks, such as the JACPHR, not only highlights his commitment to team-based science but also positions him as a valued contributor to the advancement of pediatric cardiac care. These acknowledgments reflect the trust placed in his expertise and his role in influencing the future direction of his field.

Impact and Influence

The influence of Taku Ishii’s work is evident in both direct patient care and the broader advancement of pediatric cardiology. Clinically, his interventions have improved the lives of children with complex and often life-threatening cardiac conditions. Academically, his teaching and mentorship shape the perspectives and capabilities of emerging pediatric specialists, instilling in them the values of precision, empathy, and evidence-based practice. His research, grounded in both clinical and public health perspectives, informs treatment guidelines and contributes to national health strategies aimed at better managing pediatric cardiovascular diseases. By bridging molecular research with patient care and policy considerations, he has established himself as a central figure in ensuring that scientific advances translate into tangible improvements in health outcomes.

Legacy and Future Contributions

Looking ahead, Taku Ishii is well-positioned to continue driving innovation in pediatric cardiology through cutting-edge research and collaborative initiatives. His ongoing studies in pulmonary hypertension and congenital heart disease have the potential to yield new diagnostic tools and therapeutic approaches, ultimately improving survival rates and quality of life for affected children. His interest in genetic research is likely to further integrate precision medicine into pediatric care, paving the way for individualized treatment strategies. Equally important is his role as an educator and mentor, ensuring that his knowledge and values are passed on to future generations of physicians and researchers. His legacy will be defined by both his scientific contributions and his enduring influence on the medical professionals he has trained and inspired.

Notable Publications

Pharmacological Treatment Practices for Patients with Congenital Heart Disease and Pulmonary Hypertension in Japan: Insights from the Japanese Association of Congenital Heart Disease Registry (JACPHR)

Authors: Taku Ishii; Keiko Uchida; Susumu Hosokawa; Reina Ishizaki; Naofumi F Sumitomo; Yoshiyuki Furutani; Hidekazu Ishida; Shinichi Takatsuki; Kei Inai; Kunihiko Takahashi et al.
Journal: The American Journal of Cardiology
Year: 2025

Marked improvement in severe pulmonary arterial hypertension following airway infection in a patient with a heterozygous BMP9 nonsense mutation: A case report

Authors: Taku Ishii; Makito Sakurai; Yohei Yamaguchi; Kei Takasawa; Susumu Hosokawa
Journal: — (Other publication type)
Year: 2025

Challenges in Accurately Assessing Acute Vasoreactivity in Pediatric Pulmonary Arterial Hypertension: Case Reports Highlighting the Impact of Sedation on Diagnostic Accuracy

Authors: Kana Inoue; Taku Ishii; Yohei Yamaguchi; Satoshi Nagahara; Makito Sakurai; Susumu Hosokawa; Shozaburo Doi; Diego Araiza-Garaygordobil
Journal: European Heart Journal – Case Reports
Year: 2025

Exploring viral infections’ role in Kawasaki disease onset: A study during the COVID‐19 pandemic

Authors: Taku Ishii; Nobutoshi Nawa; Susumu Hosokawa; Tomohiro Morio; Takeo Fujiwara
Journal: Journal of Medical Virology
Year: 2024

Association between the initiation of insurance coverage for fetal echocardiography and mortality from congenital heart disease in infants: An interrupted time series analysis

Authors: Taku Ishii; Nobutoshi Nawa; Shozaburo Doi; Tomohiro Morio; Takeo Fujiwara
Journal: Paediatric and Perinatal Epidemiology
Year: 2023

Conclusion

Taku Ishii’s career embodies the integration of clinical excellence, academic leadership, and research innovation. His journey from focused academic preparation to impactful professional practice demonstrates a sustained commitment to improving the lives of children with complex cardiac conditions. Through his clinical care, he offers hope and healing to patients and families; through his research, he advances the understanding and treatment of pediatric heart diseases; and through his mentorship, he shapes the future of the field. His work stands as a testament to the power of combining science, compassion, and education to create meaningful and lasting change in medicine.

Dr. Deniz Akdemir | Decision-making and Problem-solving | Best Researcher Award

Dr. Deniz Akdemir | Decision-making and Problem-solving | Best Researcher Award

NMDP, United States

Author Profile

Google Scholar 

🎓 Early Academic Pursuits

Deniz Akdemir’s journey into the world of data science and statistical genomics began with a strong academic foundation that combined both business acumen and analytical prowess. He earned his B.A. in Business Administration from the prestigious Middle East Technical University (METU) in Ankara, Turkey, in 1999. His growing interest in analytical modeling and decision-making led him to pursue a Master of Science in Statistics at METU, which he completed in 2003.

Building on this momentum, he continued his academic journey in the United States, obtaining both a Master of Arts in Applied Statistics (2004) and a Ph.D. in Statistics (2009) from Bowling Green State University. During his doctoral studies, Akdemir laid the groundwork for what would become a distinguished career in high-dimensional data analysis and computational biology. His academic training equipped him with a deep understanding of statistical theory while nurturing his talent for interdisciplinary research—a theme that would define much of his later work.

💼 Professional Endeavors

Dr. Akdemir’s professional trajectory is a blend of academia, industry, and applied research. Following the completion of his Ph.D., he held a Postdoctoral Research Associate position at University College Dublin from 2019 to 2021. During this time, he contributed to the advancement of statistical methodologies in genomic selection and experimental design.

He transitioned into the healthcare and clinical data landscape through his role at the National Marrow Donor Program (NMDP). Initially joining as a Clinical Data Scientist in 2021, Akdemir’s exceptional performance and scientific insight led to his promotion as Senior Clinical Data Scientist in 2023. At NMDP, he applies cutting-edge statistical and machine learning techniques to optimize bone marrow transplant outcomes and improve patient care—a prime example of research translating into life-saving real-world impact.

In parallel, he founded and operates StatGen Consulting, a firm that provides expert consulting services in statistical genomics and machine learning. Through StatGen, he bridges the gap between theoretical development and industry application, fostering innovation across academia, agriculture, and clinical healthcare.

🔬 Contributions and Research Focus

Deniz Akdemir is widely recognized for his pioneering contributions to statistical genomics, machine learning, and computational biology. His research revolves around developing statistical methodologies that address complex biological questions, particularly in the domains of genomic prediction, multi-trait modeling, genotype-by-environment interactions, and optimization of breeding programs.

His innovative software tools, such as TrainSel (R) and trainselpy (Python), have been instrumental in enhancing the selection of optimal training populations, improving predictive accuracy in genomic selection models. These tools are used by researchers and practitioners worldwide to streamline data-driven breeding and selection strategies.

With over 3,400 citations, 86 publications, and a growing international reputation, Akdemir’s work is a cornerstone in the statistical modeling of genomic data. His ability to integrate Bayesian methods, high-dimensional statistics, deep learning, and causal inference into biological frameworks has led to significant advances in both plant breeding and human health research.

🏆 Accolades and Recognition

While not one to seek the spotlight, Deniz Akdemir’s work has earned considerable recognition within the scientific community. His Google Scholar citation count of over 3,400 reflects the widespread adoption and influence of his methodologies. Collaborations with prominent researchers such as Jean-Luc Jannink, Mark Sorrells, Jose Crossa, and Jessica Rutkoski have resulted in high-impact publications that drive global conversations in genetics and data science.

He is also widely respected for his collaborative spirit and leadership in large-scale research projects, and his work is often cited in discussions of best practices in genomic prediction and breeding program optimization.

🌍 Impact and Influence

Dr. Akdemir’s influence extends across disciplines and continents. His statistical tools are not confined to academic research—they have practical applications in agriculture, biotechnology, and clinical medicine. His contributions help shape crop resilience strategies in the face of climate change, and inform personalized treatment strategies in hematopoietic stem cell transplantation.

Beyond the numbers, Akdemir is a mentor, educator, and thought leader. His ability to translate complex statistical theories into practical insights enables teams to make better decisions based on data. He regularly contributes to open-source communities, champions reproducible research, and supports collaborative networks across universities and institutes worldwide.

🌟 Legacy and Future Contributions

Looking ahead, Deniz Akdemir is poised to further his impact in areas where statistical innovation intersects with biological complexity. His vision for the future includes expanding the use of machine learning algorithms in healthcare, continuing to develop statistical tools that enhance breeding program efficiency, and deepening his work on genomic prediction frameworks that can transform personalized medicine.

As he continues to build bridges between disciplines and create tools that shape the future of data-driven research, Dr. Akdemir’s legacy will be that of a visionary who brought clarity, precision, and real-world impact to some of the most complex challenges in science and healthcare.

Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and More

Authors: J. Spindel, H. Begum, D. Akdemir, P. Virk, B. Collard, E. Redona, G. Atlin, J.-L. Jannink, S. McCouch
Journal: PLoS Genetics
Year: 2015

 Integrating Environmental Covariates and Crop Modeling into the Genomic Selection Framework to Predict Genotype by Environment Interactions

Authors: N. Heslot, D. Akdemir, M.E. Sorrells, J.-L. Jannink
Journal: Theoretical and Applied Genetics
Year: 2014

Training Set Optimization under Population Structure in Genomic Selection

Authors: J. Isidro, J.-L. Jannink, D. Akdemir, J. Poland, N. Heslot, M.E. Sorrells
Journal: Theoretical and Applied Genetics
Year: 2015

 Genome-Wide Prediction Models That Incorporate de novo GWAS Are a Powerful New Tool for Tropical Rice Improvement

Authors: J.E. Spindel, H. Begum, D. Akdemir, B. Collard, E. Redoña, J.-L. Jannink, S. McCouch
Journal: Heredity
Year: 2016

 Squamous Cell and Adenosquamous Carcinomas of the Gallbladder: Clinicopathological Analysis of 34 Cases Identified in 606 Carcinomas

Authors: J.C. Roa, O. Tapia, A. Cakir, O. Basturk, N. Dursun, D. Akdemir, B. Saka, V. Bagci, I.O. Dursun, N. Adsay
Journal: Modern Pathology
Year: 2011