Dr. Alejandro Meruelo | Decision-making and Problem-solving | Best Researcher Award

Dr. Alejandro Meruelo | Decision-making and Problem-solving | Best Researcher Award

UCSD, United States

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🌱 Early Academic Pursuits

Dr. Meruelo’s journey into academia and medicine began with a B.S. in Physics, awarded with honors from the California Institute of Technology (Caltech) in 2006. Recognized as a President’s Scholar, he received a full-tuition scholarship, underscoring his early academic excellence. He later joined the prestigious David Geffen School of Medicine at UCLA, where he was selected for the NIH Medical Scientist Training Program (MSTP), a dual-degree initiative supporting outstanding students who aim to integrate scientific research with medical practice. Between 2008 and 2012, Dr. Meruelo pursued a Ph.D. in Molecular and Structural Biology at UCLA, with his dissertation focusing on computational prediction and protein structure analysis—a foundation that would inform his later research into neuropsychiatry. This work, supported by the NIH Ruth L. Kirschstein NRSA Predoctoral Fellowship, introduced him to groundbreaking scientific inquiry and laid the groundwork for a career characterized by interdisciplinary exploration.

🧠 Professional Endeavors in Psychiatry and Research

Upon completing his M.D. in 2014, Dr. Meruelo undertook a rigorous Psychiatry Residency at UCSD as part of the Research Track, allowing him to blend clinical training with substantial research responsibilities. Supported by prominent grants like the R25 MH101072, he immersed himself in examining the neurological and behavioral effects of substances, particularly alcohol, on adolescents and young adults. Following his residency, he completed a postdoctoral fellowship under Dr. Susan F. Tapert, a leader in adolescent neurodevelopment and substance abuse research. This experience further refined Dr. Meruelo’s research focus on neurodevelopmental markers and risk factors associated with psychiatric disorders and substance abuse in youth. In 2019, he joined UCSD as an Assistant Adjunct Professor, where he continues to contribute to advancing psychiatry through research, clinical instruction, and community outreach.

🔬 Contributions and Research Focus

Dr. Meruelo’s research primarily focuses on understanding the neurological underpinnings of adolescent depression and the impact of alcohol use. He leads multiple funded research initiatives, most notably the National Institute on Alcohol Abuse and Alcoholism’s K23 award to explore adolescent markers of depression in relation to alcohol consumption. His pioneering studies employ functional magnetic resonance imaging (fMRI) to investigate cognitive and neural markers among youth at risk of alcoholism, which could lead to early identification and intervention for at-risk populations. Dr. Meruelo’s contributions extend to understanding structural brain changes and the long-term effects of substance use on mental health. His work has implications for early diagnosis and improved interventions in youth mental health, bridging psychiatry and neurobiology to provide holistic insights into addiction and mood disorders.

🏅 Accolades and Recognition

Throughout his academic and professional career, Dr. Meruelo has earned numerous awards that highlight his dedication and expertise. His accolades include the NIDA-AACAP Resident Training Award in Substance Abuse and Addiction and the NEI Master Psychopharmacology Program Certificate, which reflect his commitment to both understanding and treating addiction. He was also awarded the NIMH Outstanding Resident Award and attended the NIMH Brain Camp, a prestigious program aimed at fostering young leaders in mental health research. His participation in the Alcohol Medical Scholars Program and his role as a UCSD Hispanic Center of Excellence Faculty Scholar further emphasize his active engagement in promoting diversity and advancing research within the mental health field.

🌎 Impact and Influence

Dr. Meruelo’s contributions extend beyond research publications and grant-funded projects. As a lecturer in the UCSD Adult Psychiatry Residency Training Program, he influences a new generation of psychiatrists by integrating research insights with clinical applications. He actively serves on various committees, including the Diversity Committee and Neuroscience Graduate Program candidate selection, where he fosters inclusivity and academic excellence. His ad-hoc review work for journals like Biological Psychiatry and Depression and Anxiety and his contributions to the UCSD R25 Alumni Advisory Group underscore his dedication to advancing psychiatric research and mentoring. Furthermore, he has been instrumental in organizing the Interventional Psychiatry Group at UCSD, creating a platform for collaborative exploration of cutting-edge psychiatric treatments.

🌠 Legacy and Future Contributions

Dr. Meruelo’s career trajectory and research findings contribute to a broader understanding of adolescent psychiatry, particularly in relation to depression and substance use. His ongoing work holds promise for influencing preventive strategies and treatment frameworks, potentially impacting public health policies and intervention programs aimed at young people. By combining his expertise in molecular biology, neuropsychiatry, and clinical psychiatry, Dr. Meruelo continues to carve a unique path in his field. His research has not only expanded knowledge but also promises to shape future practices in psychiatry, benefiting both patients and healthcare systems.

📝Notable Publications

Cannabis and alcohol use, and the developing brain

Authors: AD Meruelo, N Castro, CI Cota, SF Tapert

Journal: Behavioural Brain Research

Year: 2017

Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood

Authors: J Jacobus, LM Squeglia, AD Meruelo, N Castro, T Brumback, JN Giedd, …

Journal: Developmental Cognitive Neuroscience

Year: 2015

Neuropsychological performance in adolescent marijuana users with co-occurring alcohol use: A three-year longitudinal study

Authors: J Jacobus, LM Squeglia, MA Infante, N Castro, T Brumback, AD Meruelo, …

Journal: Neuropsychology

Year: 2015

C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion

Authors: BJ Hwang, AD Meruelo, PW Sternberg

Journal: Oxford University Press for The Company of Biologists Limited

Year: 2007

Structural differences between thermophilic and mesophilic membrane proteins

Authors: AD Meruelo, SK Han, S Kim, JU Bowie

Journal: Protein Science

Year: 2012

Dr. Pi-Lien Hung | Decision-making and Problem-solving | Best Researcher Award

Dr. Pi-Lien Hung | Decision-making and Problem-solving | Best Researcher Award

Kaohsiung Chang Gung Memorial Hospital, Taiwan

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📋 Summary

Dr. Pi-Lien Hung is an attending physician in the Division of Pediatric Neurology at Kaohsiung Chang Gung Memorial Hospital, Taiwan. She has been serving as the Chief of Pediatric Neurology since 2013. Dr. Hung is recognized for her contributions to pediatric epilepsy, Rett syndrome, and various neurological conditions. Her work explores innovative treatments such as music therapy and the ketogenic diet, aimed at improving patient outcomes.

🎓 Education

  • Ph.D. in Clinical Medicine
    Chang Gung University, Taoyuan, Taiwan
    (September 2001 – August 2013)

💼 Professional Experience

  • Attending Physician
    Division of Pediatric Neurology, Department of Pediatrics
    Kaohsiung Chang Gung Memorial Hospital, Taiwan
    (May 2004 – Present)
  • Chief of Pediatric Neurology
    Kaohsiung Chang Gung Memorial Hospital, Taiwan
    (Since October 2013)

🔬 Research Interests

  • Pediatric Epilepsy
    Researching therapeutic approaches such as vagus nerve stimulation and therapeutic hypothermia for refractory epilepsy.
  • Rett Syndrome
    Investigating stereotypic behaviors and comorbidities in Rett syndrome patients, as well as music-based interventions for sociability repression in related mouse models.
  • Neurological Effects of the Ketogenic Diet
    Exploring metabolic profiles and EEG connectivity in children undergoing ketogenic diet therapy for epilepsy.

Notable Publications

Therapeutic effects of extracorporeal shock wave therapy on patients with spastic cerebral palsy and Rett syndrome: clinical and ultrasonographic findings

Authors: Su, T.-Y., Huang, Y.-C., Ko, J.-Y., Yu, M.-Y., Hung, P.-L.
Journal: Orphanet Journal of Rare Diseases
Year: 2024

Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

Authors: Wu, K.L.H., Liu, W.-C., Wu, C.-W., Lin, Y.-J., Hirase, H.
Journal: Journal of Nutritional Biochemistry
Year: 2024

Insights into clinical phenotypes and treatment responses in a small cohort of Taiwanese patients with SCN1A variants: A preliminary study

Authors: Syu, Y.M., Lee, I.C., Lu, J.-F., Yang, M.-T., Liang, J.-S.
Journal: Pediatrics and Neonatology
Year: 2024 (Volume, Issue, and Pages not specified)

Dravet-like syndrome with PCDH19 mutations in Taiwan ― A multicenter study

Authors: Liu, Y.-H., Liang, J.-S., Chang, M.-Y., Lee, W.-T., Lin, K.-L.
Journal: (Details not specified)

Feasibility of ketogenic diet therapy variants for refractory epilepsy in neonates to infants under 2 years old

Authors: Hsieh, T.-Y., Su, T.-Y., Hung, K.-Y., Kuo, H.-C., Hung, P.-L.
Journal: Epilepsy and Behavior
Year: 2023