Universidad de Valladolid, Spain
Author Profile
ORCID
🎓 Early Academic Pursuits
Sara Cuesta-Sancho began her academic journey with a deep-rooted curiosity for biological sciences. She earned her Licenciatura in Biology, specializing in Cellular and Molecular Biology, from the Universidad Autónoma de Madrid in 2008. This foundational degree laid the groundwork for her later interests in molecular mechanisms and host responses, especially in the context of health and disease. Her intellectual passion and academic diligence led her to pursue a Doctorate in Physiology at the Universidad Complutense de Madrid, where she conducted groundbreaking research on aging and age-related diseases in animal models. Under the mentorship of esteemed researchers—Drs. Tresguerres, Vara, and Kireev—she explored how hormonal and pharmacological interventions could modulate aging processes. Her thesis was awarded “Sobresaliente Cum Laude,” a testament to her excellence and promise as a budding scientist.
During this time, she also developed strong analytical and experimental skills that would become the cornerstone of her research trajectory. Her later decision to pursue a postgraduate qualification in Big Data and Business Analytics (2021) from UNED underscores her versatility and commitment to integrating advanced data-driven methodologies into biomedical research.
🧬 Professional Endeavors
After completing her doctorate, Dr. Cuesta-Sancho broadened her research horizons with a postdoctoral affiliation at Roswell Park Cancer Institute in Buffalo, New York, a premier institution in cancer genetics. Working in the lab of Dr. Ouchi, she immersed herself in the molecular mechanisms of DNA repair, significantly expanding her knowledge in genetic instability and oncology.
Her postdoctoral excellence earned her the prestigious Marie Curie COFUND Fellowship at the Institut de Recerca Biomèdica de Lleida, where she conducted two intensive postdoctoral stints (2016–2018 and 2018). These experiences allowed her to explore the interface between host physiology and gut microbiota, which became central to her subsequent investigations.
In 2018, she transitioned to the Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), collaborating with Dr. Girón. There, she investigated immunological responses and microbiota modulation in HIV-infected patients, cementing her profile as a leading expert in immune-microbiota interactions. Her return to Valladolid in 2021 marked a new chapter as a senior postdoctoral researcher at the IBGM-CSIC, where she focused on immune responses to emerging pathogens such as SARS-CoV-2.
Since 2022, she has balanced her research activities with teaching responsibilities as a faculty member in the Department of Pediatrics and Immunology at the University of Valladolid, becoming a tenured permanent lecturer in 2025. Her teaching includes mentorship in clinical immunology, molecular biology, and biomedical research methods.
🧪 Contributions and Research Focus
Dr. Cuesta-Sancho’s research consistently bridges molecular biology, immunology, microbiota studies, and infectious diseases. Her studies contribute to our understanding of how gut microbiota influences systemic immune responses, particularly in patients with compromised immunity such as those with HIV or COVID-19. She has also explored genomic stability and DNA repair mechanisms, illustrating her multidisciplinary breadth.
Her publication record is equally impressive, with 30 peer-reviewed research articles spanning journals of high impact. She is also experienced in securing competitive grants, having independently attracted over €120,000 in national and international funding. This highlights her prowess not only as a scientist but as a principal investigator capable of leading complex biomedical projects.
🏆 Accolades and Recognition
From receiving the Marie Curie COFUND Fellowship, one of Europe’s most prestigious postdoctoral grants, to publishing extensively and securing independent research funds, Dr. Cuesta-Sancho has accumulated accolades that recognize her scientific acumen and leadership. Her h-index of 14 reflects both the quality and the visibility of her research in the international scientific community.
Her sustained collaborations with elite institutions like the Roswell Park Cancer Institute, Universidad Complutense de Madrid, IRB Lleida, and INiBICA have further bolstered her standing in the global biomedical research network. Her track record showcases not only scientific rigor but a collaborative spirit that has enriched the academic environments she has been part of.
🌍 Impact and Influence
Dr. Cuesta-Sancho’s contributions have far-reaching implications, particularly in the fields of immunomodulation, gut microbiota, and viral immunology. Her work has advanced knowledge crucial to tackling current global health challenges such as HIV and COVID-19. Furthermore, by actively maintaining and strengthening collaborations across Europe and the United States, she has helped internationalize Spanish research and promote scientific diplomacy.
Her dual role as a researcher and educator ensures that her influence extends to the next generation of medical and life science professionals, inspiring students and early-career researchers to engage in immunological research and translational medicine.
🚀 Legacy and Future Contributions
Looking ahead, Dr. Cuesta-Sancho is poised to further her contributions in host-microbiota interactions, particularly their role in systemic diseases and immune dysregulation. With expertise spanning molecular biology, clinical immunology, and data analytics, she is uniquely positioned to lead interdisciplinary projects that can bridge basic science with clinical application.
Her legacy lies not only in her published work but in her ability to mentor, collaborate, and build bridges between institutions, disciplines, and generations. As a tenured academic with international experience, she is well-equipped to contribute to policy, curriculum innovation, and the advancement of immunological science for years to come.
📝Notable Publications
Assessment of Humoral Response at SARS-CoV-2 Infection by Multipronged Functional Proteomics Approaches
Authors: Juanes-Velasco, P.; Pérez-Arévalo, J.C.; Arias-Hidalgo, C.; Nuño-Soriano, A.; Landeira-Viñuela, A.; Corrales, F.; Bernardo, D.; Cuesta-Sancho, S.; Rojo-Rello, S.; Lécrevisse, Q. et al.
Journal: Journal of Proteome Research
Year: 2025
Soluble Oncoimmunome Signatures Predict Muscle Mass Response to Enriched Immunonutrition in Cancer Patients: Subanalysis of a Multicenter Randomized Clinical Trial
Authors: Sara Cuesta-Sancho; Juan José López Gomez; Pedro Pablo García-Luna; David Primo; Antonio J. Martínez-Ortega; Olatz Izaola; Tamara Casañas; Alicia Calleja; David Bernardo; Daniel de Luis
Journal: Nutrients
Year: 2025
Complex Immune Network and Regional Consistency in the Human Gastric Mucosa Revealed by High-Resolution Spectral Cytometry
Authors: De Prado, Á.; Cal-Sabater, P.; Fiz-López, A.; Izquierdo, S.; Corrales, D.; Pérez-Cózar, F.; H-Vázquez, J.; Arribas-Rodríguez, E.; Perez-Segurado, C.; Muñoz, Á.M. et al.
Journal: Scientific Reports
Year: 2024
Unbiased Immunome Characterisation Correlates with COVID-19 mRNA Vaccine Failure in Immunocompromised Adults
Authors: H-Vázquez, J.; Cal-Sabater, P.; Arribas-Rodríguez, E.; Fiz-López, A.; Perez-Segurado, C.; Martín-Muñoz, Á.; De Prado, Á.; Perez Mazzali, M.; de Castro, C.G.; del Hierro, A.G. et al.
Journal: Frontiers in Immunology
Year: 2024
Expression Profile of microRNAs Related with Viral Infectivity, Inflammatory Response, and Immune Activation in People Living with HIV
Authors: Cuesta-Sancho, S.; Márquez-Ruiz, D.; Illanes-Álvarez, F.; Campaña-Gómez, I.; Martín-Aspas, A.; Trujillo-Soto, M.T.; Romero, A.; Galán, F.; Rodríguez-Iglesias, M.; Márquez-Coello, M. et al.
Journal: Frontiers in Microbiology
Year: 2023