Rregeneron Pharmaceuticals | United States
Tse-Hong (Aaron) Chen is a Principal Scientist at Regeneron Pharmaceuticals, specializing in analytical chemistry and separation science for biopharmaceutical development. He earned his Ph.D. in Chemistry from Purdue University, focusing on separation science within analytical chemistry. Over his career, Dr. Chen has led analytical method strategy, development, and tech transfer for diverse therapeutic modalities, including proteins, antibodies, ADCs, siRNAs, and peptides, guiding candidates from discovery through commercial launch. His expertise encompasses non-compendial assays for drug substance release and drug product stability, material comparability, CMC strategy, and regulatory support from IND to BLA. He has authored 12 peer-reviewed articles and holds two patents, with a citation count of 261 and an h-index of 8, reflecting the impact of his work. Dr. Chen has contributed to collaborative forums in biopharma analytical strategy, mentored scientists, and supported innovation in separation techniques for purity and quantitative analysis. Recognized for his leadership and contributions to drug development, he continues to advance analytical methodologies that ensure product quality and accelerate therapeutic pipelines. His work demonstrates a strong combination of technical expertise, strategic insight, and industry impact, positioning him as a leading scientist in pharmaceutical analytical chemistry.
Featured Publications
Kwong, K. W., Chen, T. H., Luo, W., Jeddi, H., & Zhang, R. (2015). A biomimetic oxidation catalyzed by manganese (III) porphyrins and iodobenzene diacetate: Synthetic and mechanistic investigations. Inorganica Chimica Acta, 430, 176–183.
Chen, T. H., Yang, Y., Zhang, Z., Fu, C., Zhang, Q., Williams, J. D., & Wirth, M. J. (2019). Native reversed-phase liquid chromatography: A technique for LCMS of intact antibody−drug conjugates. Analytical Chemistry, 91(4), 2805–2812.
Chen, T. H., Yuan, Z., Carver, A., & Zhang, R. (2014). Visible light-promoted selective oxidation of sulfides to sulfoxides catalyzed by ruthenium porphyrins with iodobenzene diacetate. Applied Catalysis A: General, 478, 275–282.
Zhang, R., Vanover, E., Chen, T. H., & Thompson, H. (2013). Visible light-driven aerobic oxidation catalyzed by a diiron (IV) μ-oxo biscorrole complex. Applied Catalysis A: General, 464, 95–100.
Chen, T. H., Kwong, K. W., Lee, N. F., Ranburger, D., & Zhang, R. (2016). Highly efficient and chemoselective oxidation of sulfides catalyzed by iron (III) corroles with iodobenzene diacetate. Inorganica Chimica Acta, 451, 65–72.
Chen, T. H., Kwong, K. W., Carver, A., Luo, W., & Zhang, R. (2016). Enhanced iron (III) corrole-catalyzed oxidations with iodobenzene diacetate: Synthetic and mechanistic investigations. Applied Catalysis A: General, 497, 121–126.