University of Rennes and Rennes University Hospital | France
Author Profile
ORCID
Early Academic Pursuits
From the outset of his academic journey, Dr. Benoît Guillet demonstrated both ambition and perseverance in the field of medicine. His medical studies provided a strong foundation in clinical sciences and patient care, while his specialized training in biology and hematology prepared him to bridge the gap between medical research and practical healthcare applications. During his formative years, he pursued advanced degrees, including a doctoral thesis and a medical thesis, which together shaped his expertise in hematology and medical biology. These formative academic experiences were marked by rigorous clinical training, scientific inquiry, and early exposure to the realities of hospital practice, preparing him to assume responsibilities that would later expand across teaching, research, and clinical domains. His academic trajectory reflects not only intellectual excellence but also a clear vision to contribute meaningfully to both the medical and scientific communities.
Professional Endeavors
Dr. Guillet has built a distinguished professional career that spans hospital practice, academic teaching, and leadership in healthcare systems. He began his professional journey in hospital environments, where he served as an intern, assistant, and later as a hospital-university assistant. These experiences laid the groundwork for his later roles as a senior hospital practitioner and university lecturer. Over time, he assumed responsibilities that went beyond clinical practice, moving into the dual capacity of maître de conférences des universités (lecturer) and praticien hospitalier (hospital practitioner). His position at the University of Rennes and the University Hospital of Rennes has allowed him to contribute to the education of future medical professionals while delivering specialized care to patients. Through this blend of academic and hospital responsibilities, he exemplifies the modern physician-scholar, able to navigate both the practical demands of patient care and the intellectual challenges of academic medicine.
Contributions and Research Focus
One of the most notable aspects of Dr. Guillet’s career is his substantial contribution to medical research, particularly in hematology and related biomedical sciences. He has played a central role in advancing knowledge through his leadership of the CEF2VIII research group, which explores the role of endothelial cells, the liver, and Factor VIII. His engagement with Inserm U1085 (IRSET) underscores his commitment to interdisciplinary research and to addressing complex health challenges through scientific discovery. Furthermore, his position as co-coordinator of the BERHLINGO research network demonstrates his ability to foster collaborative research across institutions and regions. This network strengthens the exchange of expertise and ensures that scientific advances in hemostasis research are translated into clinical practice, improving patient outcomes. His dual focus on fundamental research and translational medicine highlights his commitment to ensuring that scientific progress directly benefits those affected by hematological disorders.
Accolades and Recognition
Dr. Guillet’s contributions to academia, hospital practice, and research have earned him numerous distinctions and responsibilities. His election to the Conseil National des Universités (CNU) in hematology reflects recognition by peers of his expertise and leadership in the discipline. Within his home institution, his appointment as Vice-Dean of the Faculty of Medicine of Rennes and as a member of the University Council illustrates the trust placed in him to guide medical education and institutional governance. Additionally, his role as President of the Electoral Commission of the Faculty of Medicine highlights his integrity and leadership within academic structures. His hospital responsibilities, including coordinating major reference centers for hemophilia and other chronic bleeding disorders, further showcase his recognized authority in the field. Each of these positions and appointments stands as testimony to his dedication, competence, and the esteem in which he is held within the medical and academic community.
Impact and Influence
Dr. Guillet’s influence extends well beyond his direct responsibilities, shaping both medical education and healthcare delivery in his region and beyond. As Vice-Dean, he has overseen critical initiatives in the modernization of health professions training and the regionalization of medical education. These efforts have contributed to improving the accessibility, quality, and relevance of medical education, ensuring that students are better prepared to meet the healthcare needs of diverse populations. His clinical leadership at the CHU of Rennes has had a transformative impact on the management of hemophilia and rare bleeding disorders, creating specialized structures that enhance patient care and support. Moreover, his research collaborations have strengthened national and international networks, contributing to scientific progress in hematology. The combination of teaching, clinical care, and research underscores his holistic approach to healthcare and amplifies his influence across multiple domains.
Legacy and Future Contributions
Looking ahead, Dr. Guillet’s legacy will undoubtedly be marked by his capacity to unify the roles of physician, educator, and researcher. His work in the field of hematology has already laid a foundation for improved diagnostic, therapeutic, and management approaches to complex blood disorders. Through his academic leadership, he has influenced generations of medical students and young researchers, instilling in them both knowledge and a model of professional integrity. His ongoing research endeavors promise further insights into the biological mechanisms underpinning hematological diseases and their clinical management. Furthermore, his involvement in national academic governance suggests that his impact will continue to shape policies in medical education and research for years to come. The breadth of his contributions ensures that his future influence will be as significant as his past achievements
Notable Publications
Immune Tolerance Induction With a Recombinant Factor VIII Fc in Haemophilia A: Data From a Chart Review Study
Authors: Robert Klamroth; Mahasen Al Saleh; Heidi Glosli; Michele Schiavulli; Benoît Guillet; Linda Bystrická; Anton Schönstein; Stefan Lethagen
Journal: European Journal of Haematology
Year: 2025
F8 gene variants influence the response to desmopressin in hemophilia A carriers
Authors: Benoît Guillet; Roseline D’Oiron; Marc Trossaert; Bénédicte Wibaut; Brigitte Pan-Petesch; Birgit Frotscher; Fabienne Genre-Volot; Laurent Ardillon; Stéphanie Desage; Céline Falaise et al.
Journal: Blood Journal
Year: 2025
The effectiveness and safety of octocog alfa in patients with hemophilia A: up to 7-year follow-up of the real-world AHEAD international study
Authors: Margareth C. Ozelo; Cedric Hermans; Manuel Carcao; Benoît Guillet; Joan Gu; Randy Guerra; Leilei Tang; Kate Khair
Journal: Therapeutic Advances in Hematology
Year: 2024
Five new F10 variants in hereditary factor x deficiency detected by high‐throughput sequencing
Authors: Cédric Pastoret; Clémentine Wahl; Sabine Castet; Fabienne Nedelec; Adeline Pontis; Sophie Bayart; Thierry Fest; Benoît Guillet
Journal: Haemophilia
Year: 2023
A focus on dominant negative variants in a series of 170 heterozygous FXI‐deficient patients
Authors: Philippe de Mazancourt; Florence Quélin; Claire Flaujac; Emmanuelle de Raucourt; Benoît Guillet; Frédéric Bauduer; Vincent Ernest; Philippe Beurrier; Aurélie Avril; Roseline d’Oiron et al.
Journal: Haemophilia
Year: 2023
Conclusion
Dr. Benoît Guillet’s career represents the ideal balance of academic rigor, clinical excellence, and leadership in medical research. From his early academic pursuits to his current roles as a university vice-dean, hospital coordinator, and research leader, he has continuously advanced both knowledge and practice in the field of hematology. His recognition at institutional and national levels highlights the trust and esteem he has earned from peers and colleagues. Through his research contributions, he has addressed critical questions in hematology, while his hospital leadership has improved care for patients with complex disorders. His enduring influence lies in his ability to shape the future of medicine through education, research, and clinical innovation. Ultimately, Dr. Guillet’s legacy is one of lasting impact, ensuring that his contributions will continue to resonate within the medical community and beyond.